Design and synthesis of N1,N5-bis[4-(5-Alkyl-1,2,4- oxadiazol-3-yl)phenyl]glutaramides as potential antifungal prodrugs

Abstract

A facile three step synthesis of a group of N1,N 5-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N1,N 5-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N 1,N5-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl] glutaramide is described. These products are designed to function as masked bis-amidine prodrugs of a promising N1,N5-bis[4-(N'- (carbamimidoyl)phenyl]glutaramide antifungal lead. © 2013 by the authors.