Warfarin and Distalgesic interaction

Abstract

Many patients receiving long-term anticoagulant treatment with warfarin require an analgesic from time to time. Current practice suggests that they should not be given acetylsalicylic acid because of an increasing risk of haemorrhage. It is common clinical practice, therefore, to recommend either paracetamol or Distalgesic for pain relief in these patients. We report two patients on warfarin who had definite haematuria when given Distalgesic (dextropropoxyphene hydrochloride and parautamol.). © 1976, British Medical Journal Publishing Group. All rights reserved.