Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. taxonomy, fermentation, isolation and physico-chemical characterization

Abstract

Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp. NR0516. It was isolated from fermentation broth by extraction with butyl alcohol, QAE-Toyopearl column chromatography and preparative HPLC. Cyclothiazomycin, which was determined to be a unique polythiazole-containing bicyclic peptide, exhibited inhibitory activity against human plasma renin with IC50 being 1.7 µM. © 1991, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.