An environmentally benign and efficient synthesis of 2-thio-substituted benzothiazoles

Abstract

An environmentally benign, simple and highly efficient method for the synthesis of 2-thio-substituted benzothiazole derivs. I (R = H, CF3; R1 = Ph, Et, n-pentyl, 4-FC6H4, 4-MeOC6H4, 2-MeOC6H4, etc.) has been reported in good to excellent yields by reacting a series of aryl halides with 2-mercapto benzothiazole, using recyclable CuFe2O4 nanoparticles under ligand free conditions in PEG-400 as solvent. In the present protocol, the copper ferrite nanoparticles can be recovered and reused up to four cycles without significant loss of activity. [on SciFinder(R)]