Neihumicin, a new cytotoxic antibiotic from micromonospora neihuensis. I. The producing organism, fermentation, isolation and biological properties

Abstract

A new cytotoxic and antifungal antibiotic, neihumicin, was isolated from the culture broth of a soil isolate identified as Micromonospora neihuensis Wu, sp. nov. Neihumicin shows in vitro cytotoxicity against KB tissue culture cells (ED50 0.94 μg/ml) as well as antifungal activity against Saccharomyces cerevisiae ATCC 9763. © 1988, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.