A New Route to Functionalized trans-Hydrindenones

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Abstract

MeAlCl2-initiated cyclization of dienone 12 provides the functionalized trans-fused hydrindenone 15 in 50% yield. Ketone 15, which is now readily available in three steps from hydrocinnamic acid via this novel cyclopentanone synthesis, has been converted to 27 and 30, thus completíng a formal total synthesis of 11-oxo Steroids. © 1983, American Chemical Society. All rights reserved.

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Snider, B. B., & Kirk, T. C. (1983). A New Route to Functionalized trans-Hydrindenones. Journal of the American Chemical Society, 105(8), 2364–2368. https://doi.org/10.1021/ja00346a043

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