USP apparatus 4 - Applying the technology

Abstract

USP Apparatus 4 is designed to determine the dissolution characteristics on a variety of dosage forms, Apparatus 4 is particularly useful for difficult dissolution analyses where the dosage form has Poor solubility or the dosage form requires a pH change of the dissolution fluid, The article, “USP Apparatus 4 (Flow Through Method) primer” (1), defined the general principles of Apparatus 4 and its advantages. This article will address the fundamentals of Apparatus 4 method development.