Abstract
An ethanolic extract of Allium tuberosum Rottl. demonstrated potent choline acetytrasferase (ChAT) activating activity (45%) among 30 screened Korean edible plants. The ChAT activator of A. tuberoum Rottl. was purified and identified as ferulic acid [4-hydroxy-3-methoxycinnamic acid] via silica-gel open-column chromatography, HPLC, EI-MS, and 1H/13C-NMR. The ferulic acid from A. tuberoum Rottl. exhibited ChAT activity in a dose-dependent manner and showed notoxicity in a cell viability assay (MTT assay). We suggest that the ferulic acid from A. tuberoum Rottl. was the strong ChAT activator.
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Kim, M. J., Choi, S. J., Kim, H. K., Kim, C. J., Hong, B., Kim, Y. J., & Shin, D. H. (2007). Activation effects of Allium tuberosum Rottl. on choline acetyltransferase. Bioscience, Biotechnology and Biochemistry, 71(1), 226–230. https://doi.org/10.1271/bbb.60314
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