CXCR4 Tropic HIV-1 gp120 Inhibition of SDF-1α-Induced Chemotaxis Requires Lck and is Associated with Cofilin Phosphorylation~!2010-04-23~!2010-05-24~!2010-06-23~!

  • Trushin S
  • Bren G
  • Badley A
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Abstract

HIV gp120 is a pleiotropic protein present in the plasma and tissues of HIV-infected patients, which affects a variety of homeostatic functions. In this report, we examine the mechanism of how gp120 blocks CD4 T cells from migrating towards SDF-1α.

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Trushin, S. A., Bren, G. D., & Badley, A. D. (2010). CXCR4 Tropic HIV-1 gp120 Inhibition of SDF-1α-Induced Chemotaxis Requires Lck and is Associated with Cofilin Phosphorylation~!2010-04-23~!2010-05-24~!2010-06-23~! The Open Virology Journal, 4(1), 157–162. https://doi.org/10.2174/1874357901004010157

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