Inhibitors of bacterial signal peptidase: A series of 6-(substituted oxyethyl)penems

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Abstract

A series of 6-(substituted oxyethyl)penem esters having the (5S) stereochemistry which are potent inhibitors of Escherichia coli leader peptidase is described. Structure-activity relationships are discussed.

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Allsop, A., Brooks, G., Edwards, P. D., Kaura, A. C., & Southgate, R. (1996). Inhibitors of bacterial signal peptidase: A series of 6-(substituted oxyethyl)penems. Journal of Antibiotics, 49(9), 921–928. https://doi.org/10.7164/antibiotics.49.921

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