Molecular imprinting electrochemical sensor for sensitive creatinine determination

Abstract

Creatinine has been considered indicative of rental condition measurement after a dialysis. In the present work, a silver nanoparticles (AgNPs)/polyoxometalate functionalized reduced graphene oxide (rGO) coated glassy carbon electrode (GCE) based molecular imprinted voltammetric biosensor was for the first time prepared for the analysis of creatinine. XRD and X-ray photoelectron spectroscopy (XPS) measurements were used for the characterization of the modified surface. The limit of detection (LOD) was obtained as 1.51 × 10-11 M, with a linear range of 0.05-1.5 nM. And the developed biosensor has been used for the detection of real specimens with desirable stability, recovery and selectivity.