Strophasterols A to D with an unprecedented steroid skeleton: From the mushroom stropharia rugosoannulata

Abstract

Skeletons in the closet: Four new compounds have been isolated from the title mushroom. The compounds display a new steroid skeleton (e.g., 1) not previously reported for steroids. Preliminary bioactivity tests show that compound 1 can protect neuronal cells by attenuating the endoplasmic reticulum stress, and has weak anti-methicillin-resistant Staphylococcus aureus activity. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.