The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines

Abstract

Background: Acetylcholinesterase (AChE) and amyloid precursor protein (APP) are implicated in Alzheimer's disease, but their specific biological roles remain unclear. Results: Overexpression or knockdown of neuronal APP modulates AChE mRNA, protein levels, and enzyme activity. Conclusion: APP can act as a transcriptional regulator through a novel mechanism independently of secretase. Significance: Understanding the physiological functions of APP will lead to a greater understanding of Alzheimer's disease etiology. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.