Avaliação da qualidade e perfil de dissolução de comprimidos de cloridrato de propranolol

Abstract

“Quality Evaluation and Dissolution Profile of Piroxicam Manipulated Capsules”. Different assays of quality control had been carried with manipulated capsules of piroxicam, designed formulations A, B and C, which had been acquired in Florianópolis, SC, Brazil. All formulations had been approved in the assays of medi- um weight and desintegration, however in the other control assays the same ones had presented irregularly. Mathematical and statistical comparative models had been used to characterize dissolution profiles of the manip- ulated capsules, reference and generic medicines of this drug. The formulations A, B, C, reference and generic had presented different efficiency of dissolution (25.02, 89.79, 84.07, 105.94, and 95.95%, respectively). The difference (f1) and similarity (f2) factors, had demonstrated that the manipulated capsules of piroxicam can not be considered equals to the reference and generic medicines. Because these results it is not possible guarantee therapeutical equivalence between manipulated and industrialized capsules of this drug. INTRODUÇÃO