Obesity-associated secondary hypogonadism in young and middle-aged men in Guangzhou: A single-centre cross-sectional study

Abstract

Aim: Male obesity-associated secondary hypogonadism (MOSH) is becoming a public health issue. We aimed to know MOSH among young and middle-aged men in our hospital, to analyse their sex hormones and other index, and to determine leptin as a risk factor for MOSH. Methods: In total, 258 men (ages ranging from 20 to 60, mean 38 ± 15) were enrolled in this study, and 242 of these men had their complete data, body mass index (BMI), waist circumference and sex hormones retrospectively investigated. The leptin and lipid levels were also evaluated, and comparisons were made between young (20-39 years old) and middle-aged (40-60 years old) men. Results: Among all the participants, 7 were thin, with a BMI < 18.5 kg/m2, 95 had a normal BMI (18.5 ≤ BMI < 23.9 kg/m2), 87 (35.9%) were overweight (24 ≤ BMI ≤ 27.9 kg/m2) and 53 (21.9%) were obese (BMI ≥ 28 kg/m2), 173 (71.5%) had a waist sized ≥ 85 cm. Among the 242 men, 104 (43%) had hypogonadism (TT ≤ 331.412 ng/dL). Compared with the men of normal weight, the level of testosterone of the obese men decreased (P =.006), while the level of serum lipids (including total cholesterol, TG and low-density lipoprotein cholesterol, P