Median lethal dose (LD50) and cytotoxicity of Adriamycin in female albino mice

Abstract

The median lethal dose of Adriamycin and its cytotoxicity in three vital organs (heart, liver and kidney) was studied. The median lethal dose (LD50) was 56.875mg/kg body. Weight (b.wt). High doses of Adriamycin induced significant increases in heart tissues enzymes (lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and Creatine Kinase-MB isoenzyme (CKMB)). Hepatotoxicity appeared in significant increment in liver function enzymes (aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) activities) and lipid profile (cholesterol and triglycerides) and significant reduction in total protein and albumin. Moreover, urea and creatinine have recorded significant increases in kidney tissues after interpretoneal administration of high doses of Adriamycin (100, 90 and 80 mg/kg b.wt.).