Prognostic significance of FoxM1 expression in non-small cell lung cancer

Abstract

Background: Various studies examined the relationship between FoxM1 overexpression with the clinical outcome in patients with non-small cell lung cancer (NSCLC), but yielded conflicting results. Methods: Electronic databases updated to Jan 01, 2015 were searched to find relevant studies. A metaanalysis was conducted with eligible studies which quantitatively evaluated the relationship between FoxM1 overexpression and survival of patients with NSCLC Survival data were aggregated and quantitatively analyzed. Results: We performed a meta-analysis of seven studies (n=860 patients) that evaluated the correlation between FoxM1 overexpression and survival in patients with NSCLC. Combined hazard ratios suggested that FoxM1 overexpression was associated with poor prognosis of overall survival (OS) (HR =1.73, 95% CI: 1.32-2.14) in patients with NSCLC. Conclusions: FoxM1 overexpression indicates a poor prognosis for patients with NSCLC.