Abstract
[11C]CGS 25966, a novel radiolabeled matrix metalloproteinase (MMP) inhibitor, has been synthesized for evaluation as new potential positron emission tomography (PET) tumor imaging agent. The precursor was labeled by [11C]methyl triflate through O-[11C]methylation method at the hydroxyl position of phenol under basic conditions and isolated by HPLC purification to produce pure target compound in 15-25% radiochemical yield, based on 11CO2, decay corrected to end of bombardment. Copyright © 2003 John Wiley & Sons, Ltd.
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Fei, X., Zheng, Q. H., Liu, X., Wang, J. Q., Stone, K. L., Miller, K. D., … Hutchins, G. D. (2003). Synthesis of MMP inhibitor radiotracer [11C]CGS 25966, a new potential PET tumor imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals, 46(4), 343–351. https://doi.org/10.1002/jlcr.675
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