Reversal of Haemostatic Changes in Letrozole-Induced PCOS Rat Model with Vitamin D Supplementation

Abstract

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine condition that appears to be associated with a prothrombotic tendency. Hypovitaminosis D is very common in PCOS patients and may exacerbate the metabolic abnormalities. Vitamin D supplementation might produce beneficial effects in these associated metabolic and haemostatic abnormalities.