A randomized crossover clinical trial of the Deseyne contact lens for presbyopia with extended depth of focus

Abstract

Purpose: To evaluate the visual performance of a new daily wear presbyopia contact lens (Deseyne contact lens for presbyopia with extended depth of focus). Methods: This was a randomized, crossover, and nondispensing clinical trial. Seventy-eight presbyopic (45–70 years, mean = 53.9 years) habitual soft contact lens wearers were recruited with spherical refractive errors between −6.00 and +4.00 D and less than 1.25 D astigmatism. Subjects were fitted bilaterally with the Deseyne lens and a control monofocal contact lens and randomized as to which of the study lenses would be tested first. Effectiveness measures included monocular lens-induced depth of focus testing—the primary effectiveness measure—and monocular distance, intermediate, and near visual acuity. Contrast sensitivity was also measured at mesopic luminance with and without glare. Results: Mean monocular distance visual acuity was 0.00 ± 0.07 and −0.07 ± 0.07 logMAR with the Deseyne and control lens, respectively. The corresponding mean monocular intermediate visual acuity was +0.02 ± 0.11 and +0.16 ± 0.14 logMAR and monocular near visual acuity was +0.20 ± 0.11 and +0.35 ± 0.17 logMAR. Mean depth of focus was 2.22 ± 0.78 D with the Deseyne lens and 1.44 ± 0.67 D with the monofocal control. The mean extended depth of focus (95% CI) was thus 0.78 (0.63, 0.93) D. Contrast sensitivity was significantly lower with the Deseyne lens at 3, 6, and 12 cycles per degree with and without glare. Conclusions: The Deseyne contact lens for presbyopia with extended depth of focus extends the depth of focus of the eye and thus improves intermediate and near visual acuity.