Influence of age and gender variations on glomerular filtration rate estimated by the MCQE formula

Abstract

Background: In clinical practice, the glomerular +ltration rate (GFR) is routinely estimated by the creatinine-based equation developed and validated from the Modi+cation of Diet in Renal Disease (MDRD) Study. However, since this formula estimates the rate of decline in GFR, the Mayo Clinic Quadratic Equation (MCQE) has been developed. Petients and methods: The purpose of this study was to assess the in:uence of age and gender variations on GFR estimated by this new equation. Results of 16,631 serum creatinine tests performed in consecutive outpatients were retrieved from the database of our Laboratory Information System. GFR was estimated by both the MDRD and MCQEformulas. Results: The di < erence in the estimated GFR between males and females was signi+cantly di < erent when calculated with either MDRD or MCQEfor-mula. Signi+cant gender di < erences were observed in all age decades by MCQEand in subjects aged > 51 years by MDRD. A s igni+cant di < erence in the mean GFR values estimated by either formula was also observed between di > erent age decades in both genders. Conclusions: The results of this epidemiological analysis indicated the MCQE formula also fail to compensate for age and gender variations.