Arsenic exposure, AS3MT polymorphism, and neuropsychological functioning among rural dwelling adults and elders: A cross-sectional study

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Abstract

Background: The aim was to examine the link between low-level arsenic exposure and cognitive functioning, and the potential role of a single nucleotide polymorphism (SNP A35991G, rs10748835) of the AS3MT gene in modifying this link. Methods: Data were analyzed on 526 participants from Project FRONTIER. Hierarchical linear regressions were created with neuropsychological raw index scores as the outcome variable and arsenic exposure and AS3MT SNP as different predictor variables. Results: Within the total sample, arsenic exposure was negatively associated with language (p∈

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Edwards, M., Hall, J., Gong, G., & O’Bryant, S. E. (2014). Arsenic exposure, AS3MT polymorphism, and neuropsychological functioning among rural dwelling adults and elders: A cross-sectional study. Environmental Health: A Global Access Science Source, 13(1). https://doi.org/10.1186/1476-069X-13-15

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