Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein

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Abstract

A trial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins, named RRP17, which is expressed specifically in cardiomyocytes, neurons, and the pancreas. RRP17 interacts with Ca2+-activated protein for secretion-1 (CAPS1), one of only a few proteins known to be associated exclusively with LDCV exocytosis. Ectopic expression of RRP17 in cardiomyocytes enhances secretion of atrial natriuretic peptide (ANP), a regulator of blood pressure and natriuresis. Conversely, genetic deletion of RRP17 in mice results in dysmorphic LDCVs, impaired ANP secretion, and hypertension. These findings identify RRP17 as a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues. © The Rockefeller University Press.

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Rybkin, I. I., Kim, M. S., Bezprozvannaya, S., Qi, X., Richardson, J. A., Plato, C. F., … Olson, E. N. (2007). Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. Journal of Cell Biology, 179(3), 527–537. https://doi.org/10.1083/jcb.200707101

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