Effect of rambutan honey (Nephelium lappaceum) acute administration on mortality, body weight, toxicity symptoms and relative organ weight of swiss websters mice

Abstract

Rambutan honey is honey from rambutan flowers nectar (Nephelium lappaceum) and known as a traditional medicine which can accelerate the oral mucosa wounds. Scientific evidence for its efficacy is widely studied, but systemic studies are still lacking. It is essential to study the impact of consumption of honey on the health. The objective of this research is to observe the effect of acute administration (14 days) of rambutan honey on male and female Swiss webster mice. The research method was an acute oral toxicity study with minor modification. Rambutan honey were administered at 625, 1250, 2500 and 5000 mg kg-1. Animals were observed for mortality, body weight changes, toxicity symptoms and relative organ weight for the next 14 days and analyzed with paired t-test and ANOVA, Tukey’s p<0.05. The results showed rambutan honey did not exhibit any abnormal signs or deaths. There was a significant increase in male mice body weight. There were no toxicity symptoms in mice. The gross necropsy analysis did not reveal changes of the organs. The conclusions of rambutan honey acute administration were safe and practically non-toxicon male and female Swiss webster mice.