Assignment of isochores for all completely sequenced vertebrate genomes using a consensus

Abstract

We show that although the currently available isochore mapping methods agree on the isochore classification of about two-thirds of the human DNA, they produce significantly different results with regard to the location of isochore boundaries and isochore length distribution. We present a new consensus isochore assignment method based on majority voting and provide IsoBase, a comprehensive on-line database of isochore maps for all completely sequenced vertebrate genomes. © 2008 Schmidt and Frishman; licensee BioMed Central Ltd.