Pharmacokinetics and residual studies of Florfenicol following multiple dose oral administration in poultry

Abstract

Pharmacokinetics of Florfenicol was established in the plasma of poultry. Florfenicol was given as multiple dose 30 mg.kg -1 orally daily for 5 days in poultry. The mean values of half-life,body clearance (Cl B) and mean volume of distribution (Vd area) were 8.39 and 7.91 h; 0.5 and 0.29 l.h -1Kkg -1 and 4.8 and 2.70 l.kg -1 after first and last dose, respectively. On the basis of depletion study for Florfenicol in poultry, a withdrawal time of 72 h was calculated. © GSP, India.