MODELING OF DRUG DISSOLUTION KINETICS WITH SIGMOIDAL BEHAVIOR FROM ORDERED MESOPOROUS SILICA

Abstract

Several models available in the literature for modeling drug release were used to describe experimental data on indomethacin dissolution from ordered mesoporous silica MCM-41 and SBA-15. Sigmoid-shape behavior observed experimentally was successfully explained by a drug release model, which relies on the concentration-dependent drug release constant. Physical reasons for such dependence are discussed. This simple model containing just two adjustable parameters could be used for treating dissolution data with sigmoid behavior. © 2014 Copyright Taylor and Francis Group, LLC.