Abstract
A quinazoline that decreases polyglutamine aggregate burden in a cell-based assay was identified from a high-throughput screen of a chemical-compound library, provided by the NIH Molecular Libraries Small Molecule Repository (MLSMR). A structure and activity study yielded leads with submicromolar potency. © 2009 Elsevier Ltd. All rights reserved.
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Rinderspacher, A., Cremona, M. L., Liu, Y., Deng, S. X., Xie, Y., Gong, G., … Landry, D. W. (2009). Potent inhibitors of Huntingtin protein aggregation in a cell-based assay. Bioorganic and Medicinal Chemistry Letters, 19(6), 1715–1717. https://doi.org/10.1016/j.bmcl.2009.01.087
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