Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

Abstract

The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATPdegrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy. © 2012 Landes Bioscience.