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cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel

Journal of Cell Biology (2022) 221(2)
DOI: 10.1083/jcb.202112021
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Abstract

Activation of the NAD hydrolase domain of Sarm1 mediates axonal degeneration caused by chemotherapy drugs, but the downstream events are unknown. In this issue, Li and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202106080) demonstrate that cADPR, a breakdown product of NAD, mediates paclitaxel-induced axonal degeneration by promoting influx of calcium into the axons.

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APA

Höke, A. (2022). cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel. Journal of Cell Biology, 221(2). https://doi.org/10.1083/jcb.202112021

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