Association of C-reactive Protein/Albumin, Procalcitonin/Albumin, Platelet/Lymphocyte, and Lymphocyte/Monocyte Ratio with Mortality in Hospitalised COVID-19 Patients

Abstract

Objective: To investigate and compare complete blood count and biochemistry parameters such as c-reactive protein/albumin (CRP/ALB) ratio, procalcitonin/albumin (PRO/ALB) ratio, lymphocyte/monocyte (LYM/MON) ratio, platelet/lymphocyte (PLT/LYM) ratio of the recovered/deceased, and ICU (intensive care unit) /ward patients with COVID-19. Study Design: An observational study. Place and Duration of Study: Department of Internal Medicine, Sakarya University Training and Research Hospital, Turkey, from April 2020 to January 2021. Methodology: The study was conducted with 590 diagnosed patients with COVID-19. The patients were divided into 2 groups as deceased (n = 294) /survivor (n = 296) and those in need of ICU (n= 418) /ward (n = 172). The information was obtained from the hospital information system and analysed retrospectively. The relationships of crp/alb, pro/alb, lym/mon, and PLT/LYM ratios with patient groups were investigated. Results: Of the total 590 patients in the study, 358 (60.6%) were males. The total mean age was 65.63 ±14.9 years. The mean age of survivor and deceased groups was 71.32±10.9 and 59.97±16.2 years, respectively (p<0.001). The mean CRP/ALBratio of the both groups was 2.32±2.42 and 5.02±3.66, respectively (p<0.001). The mean values of PRO/ALBratio for both groups were 0.096±0.53 and 0.180±0.55, respectively (p<0.001). The mean values of LYM/MONratio for both groups were 5.72±23.5 and 4.12±9.25, respectively (p<0.001). The cut-off values of crp/alb, pro/alb, LYM/MONfor the risk of mortality were found to be 2.832, 0.008, and 1.189, respectively. Conclusion: Advanced age, elevated CRP/ALB, procalcitonin/albumin, and platelet/lymphocyte ratios were found to be associated with mortality.