T TD: Ther apeutic Targ et D atabase describing tar get drugg ability inf ormation

Abstract

Target disco v ery is one of the essential steps in modern drug de v elopment, and the identification of promising t argets is fundament al for de v eloping first-in-class drug. A v ariety of methods ha v e emerged f or target assessment based on druggability analysis, which refers to the likelihood of a target being effectively modulated by drug-like agents. In the therapeutic target database (TTD), nine categories of established druggability characteristics were thus collected for 426 successful, 1 0 14 clinical trial, 212 preclinical / patented, and 1479 literature-reported targets via sy stematic re vie w. T hese characteristic categories w ere classified into three distinct perspectives: molecular interaction / regulation , human system profile and cell-based expression variation . With the rapid progression of technology and concerted effort in drug discovery, TTD and other databases were highly expected to facilitate the explorations of druggability characteristics for the discovery and validation of innovative drug target. TTD is now freely accessible at: https:// idrblab.org/ ttd/ .