IQGAP1 protein regulates nuclear localization of β-Catenin via importin-β5 protein in wnt signaling

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Abstract

Background: The molecular mechanisms underlying the β-catenin nuclear localization remain unclear. Results: IQGAP1 is a regulator of β-catenin nuclear localization. Conclusion: Importin-β5 and Ran contribute to the nuclear localization of β-catenin. Significance: Novel molecular mechanisms were found in Wnt signaling. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.

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Goto, T., Sato, A., Adachi, S., Iemura, S. I., Natsume, T., & Shibuya, H. (2013). IQGAP1 protein regulates nuclear localization of β-Catenin via importin-β5 protein in wnt signaling. Journal of Biological Chemistry, 288(51), 36351–36360. https://doi.org/10.1074/jbc.M113.520528

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