Progress in enantioselective phosphine organocatalysis

Abstract

Enantioselective phosphine organocatalysis has been a research frontier in the field of asymmetric catalysis. The comparable advantages, including short reaction time, mild reaction conditions, high catalytic activity, and environment benign, render the organocatalytic reaction to meet the development direction of green chemistry. This paper briefly reviews the recent advances in the development of chiral phosphine-catalyzed asymmetric reactions, such as Morita-Baylis-Hillman reaction, the asymmetric allylic substitution of Morita-Baylis-Hillman adducts, cycloaddition, esterification reaction, γ-addition reaction and other asymmetric reaction.