Relationship between rs1801157 polymorphism in stromal cellderived factor gene and systemic lupus erythematosus risk

Abstract

Objective: Present meta-analysis was performed to investigate the role of stromal cell-derived factor (SDF-1) gene rs1801157 polymorphism in systemic lupus erythematosus (SLE). Results: Five publications with 1,087 cases and 1,181 controls were incorporated in this meta-analysis. Overall, a marginal association between SDF-1 rs1801157 polymorphism and reduced SLE risk was found under GA vs. GG model (OR = 0.84, 95% CI = 0.70-1.00). A similar result was also observed in Asian subgroup under the same comparison after stratification analysis by ethnicity (OR = 0.79, 95% CI = 0.63-1.00). Materials and Methods: All included studies were retrieved from PubMed, EMBASE, Google Scholar Web and Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to appraise the strength of association between SDF-1 rs1801157 polymorphism and SLE risk. The stratification analysis was also performed according to ethnicity. In addition, heterogeneity was examined with Q test, and sensitivity analysis was used to test the stability of final results. Begg's funnel plot and Egger's test were adopted to evaluate publication bias. Conclusions: SDF-1 rs1801157 polymorphism may not influence the risk of SLE. However, more studies with larger sample sizes involving different populations are needed to further explore this issue.