Correlative light and electron microscopy for the analysis of cell division

Abstract

Correlative light and electron microscopy (CLEM) has recently gained increasing attention, because it enables the acquisition of dynamic as well as ultrastructural information about subcellular processes. It is the power of combining the two imaging modalities that gives additional information as compared to using the imaging techniques separately. Here, we briefly summarize two CLEM approaches for the analysis of cells in mitosis and cytokinesis. © 2013 The Authors Journal of Microscopy © 2013 Royal Microscopical Society.