Study of cytotoxic effects of CO2 extract of shigru (Moringa oleifera lam.) Root, in MCF-7 cell line of breast cancer

Abstract

Breast cancer is a disease in which abnormal breast cells grow out of control and form tumors. With being the most common type of cancer in women, breast cancer accounts for 14% of cancers in Indian women. It is reported that with every four minutes, an Indian woman is diagnosed with breast cancer. Various breast cancer cell lines have been widely used for breast cancer modeling which encompasses a panel of diseases with distinct phenotypical associations. MCF:7, a widely studied epithelial cancer cell line derived from breast adeno-carcinoma has characteristics of differentiated mammary epithelium. Ayurveda is the oldest Indian indigenous medicine system of plant drugs is known from very early times for preventing or suppressing various tumors using various natural drugs. Shigru (Moringa oleifera Lam.) is one of the most important herbal drug having Multiple phytocomponents which possess the anti:cancer property. So by using this anti: tumor property of Shigru and to prove the efficacy of Ayurvedic herbs as an alternative and cost effective source of treatment of cancer, this study has been undertaken for an In vitro study on the breast cancer cell line MF-7 by using CO2 extract of Moringa oleifera Lam. Root by using MTT assay.