Synthesis and Antiproliferative Activity of Novel Purin-8-one Derivatives

Abstract

A series of novel purin-8-one derivatives were prepared with the starting materials of 2,4-dichloro-5-nitropyrimidine and followed by multi-step reactions. The structures of all target compounds were identified by 1H NMR, 13C NMR and HRMS. The preliminary biological evaluations were performed using thiazolyl blue tetrazolium bromide (MTT) method to test their antiproliferative activities against some tumor cell lines. The results suggested that some compounds exhibited good anti-proliferative activities against tumor cell lines. Especially, four compounds showed similar or better inhibitory activities against Hela, MOLT-4 and K562 tumor cell lines compared with R-roscovitine.