Association of Renalase rs2296545 gene polymorphism to susceptibility of hypertension in Iraqi patients

Abstract

Hypertension is a major public health problem due to its high prevalence all around the globe. Renalase is involved in the regulation of blood pressure and cardiac function via degrading catecholamines in the blood circulation. This study aims to investigate the association of polymorphism of renalase gene rs(2296545) to the susceptibility of hypertension Iraqi hypertensive  patients .The results of this study revealed that the proportion of hypertensive patients with GG genotype was markedly higher with significant difference compared to controls 40% vs.5%,p≤ 0.01, CC genotype  revealed remarkable proportion among hypertensive patients.Genotype CC represented the highest percentage among  patients and healthy subjects 46% vs.70, P> 0.05.The C allele was the major allele among hypertensive patients and controls. Susceptibility analysis of renalase gene ( rs2296545) gene polymorphism with hypertension showed that GG genotype  was significant risk association among hypertensive patients in both females and males OR =12.6 ( CI 95%1.65-97.26) p≤ 0.01, while, rs2296545CG and CC are protective OR=0.41( CI95%0.11-1.50) OR=0.4 (CI95%0.13-1.17) ,P> 0.05 respectively. We conclude that  The renalase rs2296545 GG genotype and G allele could be a risk factor for hypertensive patients .