Evaluation of Antiurolithiatic Activity of Solidago virgaurea Against Ethylene Glycol Induced Renal Calculi in Rats

Abstract

Research statistics says that 12% of world's population are being suffered with Urolithiasis, where males are more prone than women. Various treatment modalities are being implemented till this decade with their respective adverse effects and recurrence rates. Current research is investigating on phytotherapy which is being considered as the safer, cost-effective therapy in treating kidney stones with low recurrence rates. Hence, We have evaluated aniturolithiatic activity of methanolic extract of whole plant of Solidago virgaurea on male albino wistar rats. MESV (250,500 and 750 mg/kg)] treatment doses were initiated from 15th day. The present study, results and the significant values reveals that the MESV has got a potential antiurolithiatic activity against experimentally induced renal calculi in rats. It can be concluded that the results indicate that the administration of MESV (750 mg/kg) reduced the biochemical parameters than the 250 and 500 mg/kg MESV and can be stated that the 750 mg/kg is an effective dose for the treatment of urolithiasis. This can be attributed by the chemical constituents like saponins, flavonoids, glycosides, polysaccharides and diuretic action.