Some aspects of distal tubular solute and water transport

Abstract

It is the aim of the present review to survey briefly some of the most prominent characteristics of distal solute and water transport and to concentrate on recent experimental data which challenge some older concepts and provide more direct evidence as to the mechanism of distal transport and its modulation. Such information has become available through the development and application of new techniques. It is apparent that the method of isolated tubular perfusion in vitro which has been developed by Burg et al. is a milestone. This method enables the direct study of hitherto inaccessible nephron segments of various layers of renal tissue.