Preimplantation development of mouse: A view from cellular behavior

Abstract

A mature animal body contains a variety of different cell types, and these cells are distributed in a well-organized fashion along the body axes. One of the major questions in developmental biology is how cells acquire different characteristics. In addition, it is important to understand how the embryo forms the body axes and how cells are allocated along these axes during development. Among mammalian species, the molecular mechanisms that regulate embryonic development have been well analyzed and characterized in mice. Here, mouse preimplantation embryonic development is briefly summarized and our current understanding of this complex process based on recent observations is reviewed. © 2010 Japanese Society of Developmental Biologists.