Research topic on Pseudomonas aeruginosa, biology, genetics, and host–pathogen interactions

Abstract

Over the years, Pseudomonas aeruginosa has served as a paradigm for the study of gene expression, metabolism, and pathogenesis. The large genome, which approaches the complexity and size of lower eukaryotes, and an abundance of regulators, facilitates adaptation to almost any environment. During evolution, competition with other prokaryotes and the acquisition of defensive mechanisms to fend off eukaryotic predators have allowed the maintenance of antibiotic-resistance markers, degradative enzymes, and secretion systems, which impact upon human infection. Eleven articles, nine of which are comprehensive reviews, are presented to highlight these topics and provide an up-to-date resource.