Electrochemical Deposition of Cisplatin on Pure Magnesium

Abstract

© The Author(s) 2018. In this research, the cisplatin has been successfully deposited on pure Mg specimen, degradable and promising for the tumor treatment by its local sustained release to prevent the cancer from metastasis and even to achieve its apoptosis. The cathodic polarization tests coupled with electrochemical reactions in various concentrations of cisplatin solutions were qualitatively and quantitatively analyzed to speculate the deposition mechanism of cisplatin by UV visible spectrometer, Fourier transform infrared spectroscopy, field emission scanning electron microscope coupled with energy-dispersive spectroscopy, focused ion beam, and X-ray diffractometer. The drug, cisplatin, is deposited on the pure Mg through exchanging Cl− with OH − , produced by the electrochemical method, to form strong hydrogen bonds for attracting one another. The FESEM images of cisplatin coated Mg specimens reveal that the diameter of cisplatin particle is around 50–150 nm with sphere-like shape. While that on cisplatin/HAp composite is less than 30 nm. Due to the high porosity, the drug loading on cisplatin/HAp coated one can be enhanced from 34.65 to 84.93 μg/cm 2 . Also, the drug release duration can be elongated from one day burst to 3 weeks sustained release, which is promising for future clinical applications.