Isosorbide dinitrate and isoxsuprine in exercise induced asthma

Abstract

Drugs which act purely on the bronchial smooth muscle (isosorbide dinitrate, isoxsuprine) may modify exercise induced asthma, showing that it is important to be sure of the exact site of action of pharmacological agents before making assumptions about the mechanisms of exercise asthma from pharmacological experiments. Our study suggests that isosorbide dinitrate would be a safe and indeed an effective preparation in patients with both chronic obstructive airways disease and ischaemic heart disease.