Abstract
A series of phosphinegold(I) thionucleobase analogues, [R 3 PAu(SR x )] (R = Et, Ph or chexyl; HSR 1 = 2‐mercaptobenzoic acid, HSR 2 = 2‐thiouracil, HSR 3 = 6‐mercaptopurine and HSR 4 = 6‐thioguanine) have been examined for their in vitro cytotoxicity in L1210 murine leukemia cells in culture. The range of ID 50 values (continuous 48 h exposure) for the complexes is 0.041 ‐ 0.131 μM. The complexes with SR 3 and SR 4 are generally the most active; however, there is no clear trend associated with the phosphine ligands.
Cite
CITATION STYLE
Tiekink, E. R. T., Cookson, P. D., Linahan, B. M., & Webster, L. K. (1994). In Vitro Antitumour Activity of Some Triorganophosphinegold(I)Thionucleobases. Metal-Based Drugs, 1(4), 299–304. https://doi.org/10.1155/mbd.1994.299
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
