Synthesis, characterization, and carbonic anhydrase inhibitory properties of silver(I) complexes of benzimidazole derivatives

Abstract

The antimicrobial properties of silver compounds and biological properties of benzimidazole derivatives have been well known for many years. In the present study, in terms of their biological potential, six novel silver(I)-N-alkylbenzimidazole derivatives were synthesized in order to examine their carbonic anhydrase (CA) inhibitory properties. All complexes were characterized by the combination of 1H NMR, 13C NMR, mass, FT-IR spectroscopic methods and elemental analyses. The inhibitory properties of all complexes were tested on the esterase activity of human CA I and II (hCA I and hCA II). Acetazolamide was used as a standard. All complexes inhibited the hCA I and hCA II activity in the range of 27.37-29.58 μM and 20.93-27.25 μM, respectively.