Relationship between intracranial pressure and critical closing pressure in patients with neurotrauma

Abstract

Background. The driving pressure gradient for cerebral perfusion is the difference between mean arterial pressure (MAP) and critical closing pressure (CCP = zero flow pressure). Therefore, determination of the difference between MAP and CCP should provide an appropriate monitoring of the effective cerebral perfusion pressure (CPP eff). Based on this concept, the authors compared conventional measurements of cerebral perfusion pressure by MAP and intracranial pressure (CPP ICP) with CPP eff. Methods: Simultaneous synchronized recordings of pressure waveforms of the radial artery and blood flow velocities of the middle cerebral artery were performed in 70 head trauma patients. CCP was calculated from pressure-flow velocity plots by linear extrapolation to zero flow. Results: Intracranial pressure measured by intraventricular probes and CCP ranged from 3 to 71 and 4 to 70 mmHg, respectively. Linear correlation between ICP and CCP was r = 0.91. CPP ICP was 77 ± 20 mmHg and did not differ from CPP eff; linear correlation was r = 0.92. However, limits of agreement were only ± 16.2 mmHg. Therefore, in 51.4% of the patients, CPP ICP overestimated CPP eff by 19.8 mmHg at most. Conclusion: Assuming that CPP eff (MAP - CCP) takes into account more determinants of cerebral downstream pressure, in individual cases, the actual gold standard of CPP determination (MAP - ICP) might overestimate the CPP eff of therapeutic significance.