A novel and efficient five-component synthesis of pyrazole based pyrido[2,3-d]pyrimidine-diones in water: A triply green synthesis

Abstract

A novel one pot synthesis of pyrazolo[4' ,3' :5,6]pyrido[2,3-d]pyrimidine-diones, via a five-component reaction, involving, hydrazine hydrate, ethyl acetoacetate, and 1,3-dimethyl barbituric acid, an appropriate aryl aldehydes and ammonium acetate catalyzed via both of heterogeneous and homogeneous catalysis in water, is reported.