Background: Most sporadic colorectal cancer (sCRC) deaths are caused by metastatic dissemination of the primary tumor. New advances in genetic profiling of sCRC suggest that the primary tumor may contain a cell population with metastatic potential. Here we compare the cytogenetic profile of primary tumors from liver metastatic versus non-metastatic sCRC. Methodology/Principal Findings: We prospectively analyzed the frequency of numerical/structural abnormalities of chromosomes 1, 7, 8, 13, 14, 17, 18, 20, and 22 by iFISH in 58 sCRC patients: thirty-one non-metastatic (54%) vs. 27 metastatic (46%) disease. From a total of 18 probes, significant differences emerged only for the 17p11.2 and 22q11.2 chromosomal regions. Patients with liver metastatic sCRC showed an increased frequency of del(17p11.2) (10% vs. 67%;p
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González-González, M., Muñoz-Bellvis, L., Mackintosh, C., Fontanillo, C., Gutiérrez, M. L., Abad, M. M., … María Sayagués, J. (2012). Prognostic impact of del(17p) and del(22q) as assessed by interphase FISH in sporadic colorectal carcinomas. PLoS ONE, 7(8). https://doi.org/10.1371/journal.pone.0042683
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